Test Puzzle

Instructions In a logic puzzle you are given a series of categories, and an equal number of options within each category. Each option is used once and only once. Your goal is to figure out which options are linked together based on a series of given clues. Each puzzle has only one unique solution, and each can be solved using simple logical processes (i. e. educated guesses are not required). A custom-labelled grid is provided for every puzzle, like the one you see to the right.The grid allows you to cross-reference every possible option in every category. You can eliminate pairs you know aren't true with an X, and pencil in pairs you know are related with an O. If you know, for example, that Lauren wasn't born in 1961, you can add an X in the box where the Lauren column and 1961 row meet. Similarly, if you know that Bryant was born in 1971, you can add an O in the appropriate box.Furthermore, since every option can only be used once in any given puzzle, you can eliminate the four ot her options for Bryant in that category (1937, 1946, 1961, 1975) and the four other options for 1971 (Anahi, Jayden, Lauren and Nikolas). Continue doing this for every clue you're given. Eventually you will have filled in enough X's and O's on the board that you will then be able to use simple logic to deduce the solution to the puzzle. For example, if A = B, and B = C, then A must equal C.Similarly, if A = B, and B =/= D, then A must not equal D. School Crimes Five naughty school kids each were up to mischief and were all caught in the act. What was each child's name, what did each child do and what was their punishment? Clues 1. Bethany was made to stand up in Assembly and sing the nursery rhyme ‘Hickory Dickory Dock' for her heinous crime, which did not involve super glue or eating in class. 2. Bart's punishment was not detention or running 10 laps. 3. Writing lines about politeness was the punishment for the child that stuck heir tongue out at the teacher; this wasn't Bart . 4. The punishment of running 10 laps around the school field was not for using super glue on a teacher's chair; was this Chad? 5. Brenda did not get detention, which she would have preferred, and her crime wasn't to stick out her tongue. 6. Charles' crime was to persistently burp in class, much to the amusement of his pals. 7 . Scribbling on the desk did not have the punishment of cleaning the teacher's shoes. Answer grid Name| Mischievous act| Punishment| | | | | | | | | | | | | | | |

Diabetes Presentation Essay

Learning Team A was tasked to create a 15-20 slide presentation of a major health issue  prevalent in the United States. The group  chose the disease diabetes.  Diabetes is a disease that affects how your body  uses blood glucose. The glucose in your body is  important because it is an important source of  energy for the cells that make up our muscles and  tissues. It is the main source of fuel for our brain. Mellitus- Also known as Type 1 Diabetes, TD1; formerly insulin dependent diabetes or juvenile  diabetes.  Is a form of diabetes mellitus that results from the autoimmune destruction of the insulin-producing  beta cells in the pancreas. The subsequent lack of  insulin leads to increased blood and urine glucose. Polyuria (Frequent Urination) Polydipsia (Increased Thirst) Fatigue Weight Loss Blurred Vision Smell of acetone on the breath Abdominal Pain Nausea Diabetes Mellitus- Also known as  Type 2;formerly noninsulin-dependent diabetes  mellitus (NIDDM),or adult-onset diabetes. Diabetes Mellitus-Is a metabolic disorder that is  characterized by high blood sugar disorder where it  is insulin resistance and relative to the lack of  insulin. Polyuria (Frequent Urination) Vaginal Infections Fatigue Blurred Vision Weight Loss Itchiness Peripheral Neuropathy Glycosuria Gestational  diabetes starts when your body is not  able to make and use all the insulin it needs for  pregnancy. Without enough insulin, glucose cannot  leave the blood and be changed  to energy. Glucose builds up in the blood to high  levels. This is called hyperglycemia. Gestational  diabetes affects the mother in late  pregnancy, after the baby’s body has been formed,  but while the baby is busy growing. untreated or  poorly controlled gestational diabetes can hurt your  baby. When you have gestational diabetes, your  pancreas works overtime to produce insulin, but the  insulin does not lower your blood glucose levels. levels. Although  insulin does not cross the placenta,  glucose and other nutrients do. So extra blood  glucose goes through the placenta, giving the baby  high blood glucose levels. This causes the  baby’s pancreas to make extra insulin to get rid of  the blood glucose. Since the baby is getting more  energy than it needs to grow and develop, the extra  energy is stored as fat. This  can lead to macrosomia, or a â€Å"fat†Ã‚  baby. Babies with macrosomia face health problems  of their own, including damage to their shoulders  during birth. Because of the extra insulin made by  the baby’s pancreas, newborns may have very low  blood glucose levels at birth and are also at higher  risk for breathing problems. Babies with excess  insulin become children who are at risk  for obesity and adults who are at risk for type 2  diabetes. Gestational diabetes  doesn’t cause  noticeable signs or symptoms. Rarely,  gestational diabetes may cause  excessive thirst or increased urination. According to the National Diabetes Education Program these are the risk factors for diabetes: 45 years old or older. Overweight – BMI > 23 for Asian American, 26 for Pacific Islander, or 25 for anyone else.  Have a parent, brother, or sister with the disease. Family background is African American, Hispanic/Latino, American Indian, Asian American, or Pacific Islander. I have had diabetes while pregnant (gestational  diabetes) or gave birth to a baby weighing 9 pounds  or more. Have  been told that blood glucose (blood sugar)  levels are higher than normal. Have high blood pressure. Cholesterol levels are not normal – HDL (â€Å"good†)  cholesterol levels less than 35 or triglyceride level  higher than 250. Fairly inactive, physically active less than 3 times a  week. Have polycystic ovary syndrome (a set of symptoms  related to a hormonal imbalance that occurs in  females of reproductive age). The  skin around the neck or in armpits appears dirty  no matter how much it is scrubbed. The skin  appears dark, thick, and velvety. This is called  acanthosis nigricans. Have been told that have blood vessel problems  affecting the heart, brain, or legs. Set  a weight loss goal – The key to preventing  diabetes is to lose weight by eating healthy foods  that are lower in fat and calories and being  physically active. Set a goal that you can achieve,  they recommend 5 to 10 percent of your current  weight. Make healthy food choices – There are many weight  loss plans to choose from, but the DPP (Diabetes  Prevention Plan) showed that you can prevent or  delay the onset of diabetes by losing weight through  a low-fat, reduced calorie eating plan. Move  more – Try to get at least 30 minutes of  moderate-intensity physical activity five days a  week. If you have not been active, start off slowly,  building up to your goal. Any physical activity that  gets your heart rate up will do; walking, dancing,  swimming, biking, etc. You don’t have to do all 30  minutes at once, doing 10 minute sessions  throughout the day is fine. Diabetes is a endocrine systems disorder but affects all systems of the body: Eyes- Diabetes can damage the blood vessels in your eyes. This damage can lead to glaucoma, cataracts, structural changes to your retina, even blindness. When blood vessels are damaged, nerve signals can’t reach your eyes. In addition, having diabetes can lead to a buildup of pressure from fluid, which can compress nerves and other structures in your eye. Having a high level of blood sugar makes your kidneys work harder to filter your blood, and they can become overworked. This can lead to chronic kidney disease and complete failure. Having diabetes can also cause damage to your liver and cause a condition called nonalcoholic fatty liver disease. This means your liver is having difficulty processing fats. You may develop scar tissue on your liver and a condition called cirrhosis. Too much glucose circulating in the blood can damage any of the nerves in your body. This can lead to numbness, tingling and pain, especially in the legs and feet. If you develop cuts or sores you may not feel them, and they may heal very slowly. You may lose sensation in these areas, and if the damage is severe enough, amputations may be necessary. In  conclusion, diabetes can be potentially deadly  disease, effecting the whole body if left untreated. It  can however be easily managed through diet and  exercise, perhaps even avoided entirely by  practicing healthy eating habits and maintaining  regular exercise throughout life.

Amst 301

AMERICAN STUDIES 301 MIDTERM Please include a title for the midterm, TA name, and staple Description of assignment: Compose an anthology of thirteen quotations drawn from the materials assigned for the first three sections of this course (Parts I, II and III). The anthology will consist of a preface, short commentaries on each quotation, and a conclusion. The anthology should be governed by a theme (or a set of two topics aligned to the concerns of the first four sections of the syllabus) that offer a way to unite together the diverse materials for this course.The best anthologies (those that will receive an A or A- grade) will be ones where the theme enables the student to inquire into the complexities of American culture and where both the structure and content of the midterm manifest democratic thinking (i. e. , examining an issue by looking at it from multiple points of view) and integrative thinking (i. e, finding similarities or making syntheses between separate, diverse voices ). Texts for the assignment: Draw one quotation from each of the following texts or set of texts.Present the quotation and cite the text and page number of the quote (if the page number is available). Then provide your analysis of the quotation. Note: You should feel free and encouraged to arrange the quotes and commentaries in whatever order you find most appropriate and compelling. It’s best not to arrange the quotes in the order presented in the list of texts that follows. Compose an arrangement that allows you to create the most interesting and revealing conversation—or dialogue and debate–among the texts. . Carroll, ed. , Letters from a Nation 2. Katz, ed. , Why Freedom Matters 3. Smith, Twilight: Los Angeles, 1992 4. Cumings, Dominion from Sea to Sea, chapters 2, 10 or 11 5. O'Hearn, ed. , Half + Half: Writers on Growing Up Biracial and Bicultural 6. Essays on Los Angeles by Christopher Isherwood, Sonora McKeller, Wanda Coleman, Jimmy Santiago Baca, Lynell George, or Bill Bradley. 7. Political oratory or writings by John Winthrop, Abigail Adams, Thomas Jefferson or Frederick Douglass 8.Herman Melville, â€Å"Bartleby, the Scrivener: A Story of Wall Street† or Nathaniel Hawthorne, â€Å"A Gray Champion† 9. Black, Our Constitution: The Myth That Binds Us 10. Political oratory by Woodrow Wilson, Franklin Roosevelt, Martin Luther King, Jr. , Thurgood Marshall, Mario Cuomo, Ronald Reagan, Barack Obama, or Bernie Sanders. 11. Essays or Speeches by Tony Kushner, James Baldwin, Stanley Crouch or Cornell West 12. Poetry by Pat Mora, Gloria Anzaldua, Ariana Waynes, Beau Sia, Steve Connell, Langston Hughes, or lines from comedy skits and writings by Culture Clash 13.John Leland, Hip: The History, David Brooks, On Paradise Drive: How We Live Now (and Always Have) in the Future Tense, or any quotation of your own selection drawn from American music, film, literature, history, politics, including lines from movies or lyrics from a so ng. Analysis of the texts: Write a commentary on each quotation that is between 3-5 sentences in length. The commentary should be more than a paraphrase of the passage: it should seek to illuminate the significance of the passage and connect the passage to other passages through comparisons and contrasts.The commentary should develop the theme or governing idea of the anthology as a whole. It is vital in these commentaries to explicate the passage first and foremost from the point of view of its author rather than to offer your personal opinion of it. Consider the commentary an act of empathic listening and of comparative or contextual analysis. Seek to understand the passage in its own context rather than just declaring its personal significance to you. Comment on the language and specific details of the passage and make both comparisons and contrasts to other texts in the anthology.Preface : Write a 1-2 page Preface to this anthology in which you introduce and explain the orchestr ating theme or themes of this anthology—-the topics, concerns, issues, arguments that govern selection of the quotations you use to compose this anthology. The Preface should be similar to a presenting a thesis to a 5-7 page critical essay in Writing 140 or 340. Conclusion: Conclude the anthology with a paragraph in which you briefly explain which text or reading assignment was most important for your education so far.Select the one text or assigned reading that you feel should definitely be included in the syllabus when I teach this course in a future semester. The task of this anthology (beyond revealing that you have studied the wide range of materials assigned so far for this course) is to find sources of unity in the diversity of the materials. Advice for the Midterm When commenting upon texts for the midterm and when choosing a theme or set of themes to orchestrate your midterm anthology, I recommend that you keep in mind the approaches of Anna Deavere Smith and Michael Kammen to American culture as described below.Smith believes that words can be â€Å"the doorway into the soul of a culture,† and in Talk to Me: Listening Between the Lines (2000), she writes, â€Å"I set out across America, on a search for American character. My search was specifically to find America in its language. I interview people and communities about the events of our time, in the hope that I will be able to absorb America†¦. This is a country of many tongues, even if we stick to English. Placing myself in other people’s words, as in placing myself in other people’s shoes, has given me the opportunity to get below the surface—to get ‘real. † When you comment upon these texts, try to place yourself â€Å"in other people’s words† as if placing yourself â€Å"in their shoes. † Listen to what is said and what may be hidden between the lines, and comment upon both. Consider also what might be revealed about a te xt by comparing and contrasting its words with voices from other texts or by juxtaposing its words against the words of a different text. Compose this anthology, in other words, by â€Å"downloading† and â€Å"mixing† and â€Å"sampling† voices to burn your own CD representing and reflecting upon the â€Å"American sound. And just as in Hendrix’s version of â€Å"The Star Spangled Banner,† your anthology can give us sounds and voices of dissonance as well as harmony. Smith also writes in Talk to Me: â€Å"My pursuit of American character is, basically, a pursuit of difference. Character lives in that which is unique. What is unique about America is the extent to which it does, from time to time, pull off being a merged culture. Finding American character is a process of looking at fragments, of looking at the unmerged. One has to do the footwork, one has to move from place to place, one has to stand outside. Your anthology will be composed of a s et of 12 quotations, and each quotation can be considered a fragment. When commenting upon each fragment or text, try to relate the fragment to other fragments. Seek out and explain places of merger or agreement among the fragments. But also be willing to see each fragment as unique, as a different take or look or perspective on your theme. The various quotations will come from different places, different times, and along with noting the specific time and place of each quotation, you should note on occasion how the quotations differ or disagree with each other.The anthology should, in effect, create a conversation and dialogue and debate—or a drama or a jazz performance–among the texts, playing one text off another. Consider each voice a solo or a monologue whose performance you analyze, but let your commentaries and the structure of the anthology as a whole be a jazz orchestra, or a play, or a congress of voices checking and balancing each other. A crucial part of the anthology will be your selection of a theme or themes that will enable you to unite together the different materials for the course.If you conceive of the anthology as part of an attempt to understand some aspect of the â€Å"American character,† you can follow the path of Michael Kammen who advises us to seek out paradoxes and contradictions within American culture. He notes that many have tried to provide a master key to unlock the mystery of the American character, proposing such single explanations as the Puritan sense of mission, the westward movement of the frontier, the desire for opportunity and open land, the effects of immigration, or the story of freedom.But any â€Å"quest for national character, culture, or style,† Kammen cautions, â€Å"plunges one into a tangle of complex historical considerations,† and he draws upon the writings of Erik Erikson to remind us, â€Å"It is commonplace to state that whatever one may come to consider a truly America n trait can be shown to have its equally characteristic opposite. † There is no simple answer and no one right answer to the question: â€Å"What is the American character? You might say that America is a place of â€Å"mixed messages† and that it will take some â€Å"hard work† to understand the complexity of the struggle for democracy, freedom, justice, equality, and a more perfect union in America. Godfrey Hodgson in his book, More Equal Than Others: American from Nixon to the New Century (2004) gives us an wonderful update on Kammen’s attempt to see Americans as a â€Å"people of paradox. † Hodgson writes, â€Å"At the beginning of of the twenty-first century, the United States was a mature civilization marked by striking, well-rooted contradictions.It is (and the list of pairs by no means exhausts the difficulties facing anyone who attempts a simplistic analysis) generally pacific but occasionally bellicose; religious yet secular; innovative but conservative; tough but tender; aggressive yet reluctant to incur casualties; egalitarian by instinct but stratified in tiers of wide and growing inequality; puritan yet self-indulgent; conformist but full of independent-minded people; devoted to justice, but in many ways remarkably unfair; idealistic yet given to cynicism. (â€Å"Nice guys finish last† is almost a national motto. At some times it can be self-confident to the verge of complacency, at others self-doubting to the point of neurosis. † When choosing a theme for you anthology, I recommend that you search for a topic that allows you to study America by highlighting at least one or two of the contradictions or paradoxes within its â€Å"character. † You can draw upon the list of contradictions/paradoxes/ tensions/conflicts as possible topics of themes for your anthology. Freedom vs. Tyranny Liberty vs. Slavery Equality vs. Hierarchy (or Supremacy) Democracy vs. Monarchy/Aristocracy or Imperialism/Em pire Democracy vs.Racism/Sexism (or the Tyranny of the Majority) Tradition vs. Revolution/Innovation Purity (or virtue) vs. corruption Exclusion vs. Inclusion Culture clash—culture merger Memory (studying the past) vs. Forgetting (letting go, living in the present) Born to Run/Born to be Wild vs. Stability/Civilization/the Home The Founding Fathers Know Best vs. The Sins of the Fathers Democracy vs. Theocracy Church—State Religion—politics Letter of the law—spirit of the law (or a higher law) Unity—-diversity Melting pot—-mosaic Assimilation—roots Majority–Minority Insiders—outsiders (outcasts) More perfect union—individualismSelf-interest vs. fraternity (brotherhood) Care for self vs. Care for others (caritas) Materialism—-spirituality Gold—God Success-failure Happiness—misery Blues–gospel Mobility-fixity Tradition—innovation Conformity—revolt Parents—children (gen erational conflict) Machismo—feminismo Country—city Civilization—savagery Hope—-fear Privilege—equality Reverence–irreverence Authority—-rebellion Provincialism—cosmopolitanism Country-city Myth vs. history Stories we want to hear vs. stories we need to hear Format: Title Preface 1. Anna Deavere Smith, Talk to Me: Listening Between the Lines (2000):I set our across America, on a search for American character. My search was specifically to find America in its language. I interview people and communities about the events of our time, in the hope that I will be able to absorb America†¦. This is a country of many tongues, even if we stick to English. Placing myself in other people’s words, as in placing myself in other people’s shoes, has given me the opportunity to get below the surface—to get ‘real. ’ (p. 12) 3-5 sentences of commentary 2. Author, title quotation: xxxxxxxxxxx 3-5 sentences o f commentary Conclusion

Teams Essay Example | Topics and Well Written Essays - 1000 words

Teams - Essay Example A set of strategies perceived to be suited to rectifying the Team's collaboration and sense of belongingness will be presented. Finally, a conclusion shall synthesise the main points of this paper, and reiterate the support for a team-centred culture, represented by the procedural manual, as a solution to the current Team environment. 1) Value: Having the ability to work independently - this is a value inherent in the role of an 'independent worker'. The employee is able to organize themselves, set goals, manage time, maintain their progress and evaluate their outcomes. Being able to rely on their skills and knowledge to achieve a task, the independent worker is self-reliant and often takes the initiative. Furthermore, when entering into a group assignment, the independent worker brings a wealth of knowledge, skills and competencies that contribute to the development of the group. Such diversity cultivates empathy, tolerance for differences, and appreciation for another's point of view. 2) Value: Distributed Responsibility and Leadership - each member of the Team acknowledges their accountability for their decisions and actions, and accepts that a combination of leadership styles must be available to guide and monitor group development. This value includes the consensus that a Team member needs to act in a professional manner, and that this requires a commitment to the group assignment. 3) Value: Communication - to consider others in our interactions, by being open and sincere in or contributions and conferencing. Each member of the group is expected to support the group and interact with other members to plan, problem solve and discuss Team issues. Each person will be listened to and provided with the opportunity to speak freely of their issue or suggestion. Members are encouraged to express their reservations with the current procedures and processes, as this will enhance the accuracy and relevance of the manual, as well as encourage group members to form bonds of trust, support, consideration and overall coherence. 4) Behavior - Democratic Vote - A decision will be made by the majority. As such, all members will have the opportunity to voice their points of view, while at the same time being required to justify their position. Issues which require a vote must have all Team members present. However, if the decision made is later evaluated and found to be lacking in effectiveness it will be revised and modified. 5) Behavior: Motivation - The Team aims to encourage and support each member, as when asking them about their job and issues at work. As a group, solutions will be brainstormed so that it is not the independent worker with the sole responsibility for progressing toward set goals. The Operations Manager will also review Team Development and comment on goals and progress. At meetings, praise is given for achievements, both as a group, and as individuals contributing to the group.Now to turn to the identified strengths and weaknesses of the Team's culture. Firstly, it is a strength that the Team decided upon a set of core

In Mexico, Wal-mart is defying its critics Article

In Mexico, Wal-mart is defying its critics - Article Example However, when everything had been considered, it became clear that microeconomics and macroeconomics had made people (especially those in small towns) poorer. The solution was to improve their purchasing power by offering them commodities at the lowest possible prices, lower than what local retailers were offering. In retrospect, it is safe to say that macroeconomics and microeconomics had a huge impact on Wal-Mart’s strategy in Mexico. The biggest retailer in the world had to develop a pricing strategy that would enable it to enter and remain in the Mexican retail segment. It is not often that a scenario like this is witnessed, especially when a large company like Wal-Mart is involved, but the economic conditions in Mexico meant that the company had to conform or go and try its luck elsewhere. Its pricing strategy is particularly damning evidence that the target market always dictates company approach and business strategy. Poor Mexican people were not going to work harder in order to afford Wal-Mart’s products; the company had to conform to their needs by formulating its pricing and accessibility around them and their purchasing power. That is the influence of macroeconomics and

An Emergent Method of Ground Theory for Conducting Social Research Essay - 9

An Emergent Method of Ground Theory for Conducting Social Research - Essay Example Grounded Theory or GT is a form of qualitative research which is more like a descriptive methodology rather than what the advocates of quantitative research described as the more accurate and scientific method of research using numbers as precise, systematic indicators. Grounded Theory as a qualitative form of research has many benefits and the results obtained in using GT can likewise be considered as equally valid or legitimate just like quantitative methods. Grounded Theory offers flexibility not possible with numbers alone (Charmaz, 2000, p. 510). Charmaz had posited the idea that Grounded Theory is superior when used or utilized in the conduct of social science research that basically involves people. Many areas of academic disciplines for inquiry include economics, politics, demography, sociology, history, law, and linguistics. Social science studies human behaviors, the individuals in a society, and relationships of these individuals among themselves and to the larger society. As such, it is considered that the use of numbers alone (qualitative research methodology) is not sufficient to describe people. Grounded Theory as an emergent method for conducting social research inquiries offers benefits not available with quantitative research alone. GT offers the richness of nuances that are observed when watching people, how they behave, and what their likely actions will be in future situations or events. GT as an emergent method begins with the empirical world and builds up an understanding of it as events unfold and knowledge accrues or accumulates through inductive reasoning (Charmaz, 2008, p. 155). The use of GT, therefore, affords the advantages of flexibility for social scientists to study their research problems in unanticipated ways and newer directions than would otherwise be possible if they used quantitative research methodology which is quite narrow and limited as to its research objectives set out at the very beginning of a research study. In other words, let their research data lead them to wherever it might lead them to.

Mercury Contamination in Fish Research Paper Example | Topics and Well Written Essays - 1000 words

Mercury Contamination in Fish - Research Paper Example The paper is based on two studies carried out in Bangladesh and the U.S. In the first study, Rees et al. (2007) aimed at elucidating how toenail mercury is related to dietary fish consumption in New Hampshire. In the second study (Bangladesh study), Shamshad, Shahidur, and Tasrena, (2009) focused on determining the level of trace elements (including mercury) in fish feed and shrimp sampled from aquaculture ponds. Mercury is an established heavy metal, environmental pollutant with deleterious health effects in human beings (Eisler, 2006). Mercury toxins lead to neurological impairment in humans (National Research Council, 1978). Mercury in contaminated fish food consumed by pregnant women may affect the unborn baby’s brain and nervous system. Children who were affected by mercury while in the womb have poor cognitive thinking and memory and reduced concentration (Health Effects, 2012). Studies have proved that adults, children and developing fetuses are in danger of mercury intoxication (National Research Council, 1978). Schmitt, Stricker and Brumbaugh (2011, p. 1) argue that methyl mercury concentrations in some U.S species of fish (Micropterus dolomieu and Hypentelium nigricans) â€Å"are significantly high to represent a threat to human health and wildlife†. The U.S has a high risk of suffering from mercury intoxication consumed from fish compared to Bangladesh, in spite of Ba ngladesh having more fish than the U.S. Studies on mercury intoxication are essential because they enable stake holders to devise preventative measures. Thus, this paper examines the effect of mercury toxins in fish in Bangladesh and the U.S. The graph below is an example showing comparing levels of mercury in blood lead and the risk for autism in children. The graph indicates a significant correlation between the two variables. Figure 1: Graph indicating the distribution of Hg levels in ‘charge children’, comparing four groups: regressive autism, autism of early onset, general population controls and developmentally delayed children. Source: http://cfpub.epa.gov/ncer_abstracts/index.cfm/fuseaction/display.highlight/abstract/1773/report/F Materials and Methods The Bangladesh study assessed the level of trace elements content in fish feed and shrimp sampled from aquaculture ponds in Bangladesh by the use of Flame Atomic Absorption Spectrometer (FAAS), Cold Vapor Absorpti on Spectrometer (CV-AAS), and Hydride Generation Atomic Absorption Spectrometer (HG-AAS). The study was based on the theoretical assumption that since tannery and poultry waste are used as fish feed in Bangladesh, there is an accumulation of toxic contaminants in cultured fish posing food safety risk. Toxic metals including mercury are used in the manufacture of tanneries, dye production, textile dying and paper and pulp mills. Two samples of Shrimp and twelve samples of the feed were collected from different aquaculture sites in Bangladesh. The sample was washed by de-ionized water and then air-dried. They were then analyzed using FAAS, CV-AAS and HG-AAS (Shamshad, Shahidur, & Tasrena, 2009). The American study was conducted as follows: method one; participants observed a 3 day diary of water and seafood consumption which facilitated the calculation of the average consumption of finfish and shell fish on a weekly basis. Method two; the average weekly consumption of fish (shell fish , tuna and dark fish) was estimated using semi quantitative food frequency questionnaire. Method three; the weekly consumpti

CHILD TUTORING cASE sTUDY Essay Example | Topics and Well Written Essays - 750 words

CHILD TUTORING cASE sTUDY - Essay Example The children are divided amongst the women depending on his or her age group. I was allowed to choose the grade level I preferred to work with and so I chose second grade. Therefore, I was assigned to tutor in Ms. Sally’s room. The children in this room ranged in age from six to nine years old. I worked with a nine year old African American girl that I will call Kayla. Kayla is in the third grade at a Birmingham public school. When I first met Kayla, I would have never guessed that she was only nine years old. Kayla is a very bright and intelligent child. However, she craves love and attention. I immediately noticed that she had a very firm tone and wanted things done her way or no way. So, I decided to just observe her on the first day, before beginning the tutoring. This allowed me the opportunity to observe her characteristics and how well she worked with other children. I engaged in â€Å"best practices† by using data and collecting information to find a selective approach to building a partnership with her. Kayla has a very distinctive personality and used her superior strength to intimidate others. She would walk in the classroom and demand items from the other children who were intimidated by her. This led me to believe that Kayla had older siblings, family m embers, or friends that treated her roughly. According to Dr. Jane St. Clair, children who act out in this manner are referred to as bullies. â€Å"Bullies usually have a sense of entitlement and superiority over others, and lack compassion, impulse control and social skills. They enjoy being cruel to others and sometimes use bullying as an anger management tool, the way a normally angry person would punch a pillow† (St. Clair, n.d.). I didn’t want Kayla to think I was there to just interview her, so I carefully made conversation and asked questions that gave me enough insight on her background. For example, I told Kayla I had one sister and two brothers. This

Personal Statement + Answering a Question Example | Topics and Well Written Essays - 750 words

+ Answering a Question - Personal Statement Example I was overwhelmed with joy after securing admission into North Seattle College to study for an Associate Business (AB) degree. My success in high school meant a lot to me and to my family as well. It was the first time I was in overseas country after securing a scholarship to study abroad away from home. I worked so hard to ensure I triumphed in the business school in order to secure a possible scholarship to further my studies. However, a fateful event happened one early morning as I was rushing to class to prepare for my first end of semester exam. I had just alighted the bus and was preparing to cross the road and walk into the school compound when I saw a speeding SUV screech to a halt at the forefront of a computer sales shop. Two masked gunmen emerged from the vehicle and ran into the shop. A few moments later, they ran back into the vehicle and sped off. Whereas I could figure out a robbery had just happened, I could not imagine that the shop attendant was already injured. It was a critical moment for me because I was torn between rushing to school and prepare for my exams or help the badly injured person. In a flash of a second, I remembered a court case where a volunteer had been mistaken as a murderer because his fingerprints were found on a dead man’s body. The case had lasted for more than five years until the man was finally cleared of the murder charges and the real murderers put in jail. However, I could see the collapsed man was bleeding profusely and had lost consciousness. Being an early morning, there was hardly anybody passing by. At that moment, I had two choices, save a life and compromise my grades in college or just run to school and leave the man helpless. Additionally, I could think of the after effects of helping the person. The police would take my valuable college time through endless interrogations, as I would be a key witness. I resolved to

Business Forecasting Essay Example | Topics and Well Written Essays - 750 words

Business Forecasting - Essay Example Business forecasting can be done using two methods as covered in this paper. This method of forecasting depends on the market experts and thus short-term predictions are best situated for this method of forecasting. For the method to work and attain the desired goals of the company, then experts must be involved in financial statements so as to predict and rely on measures that can be followed. If the measures outlined by the experts are followed, then short term goals and success will be accomplished (McKinley and Lee, 2005). The only disadvantage of the qualitative method of forecasting is that the management of the companies relies on the opinions of individuals or the experts who estimate the budget and provide the measurable data that is going to be used in the company. For this method to be successful in any organization then it will involve the following aspects. This simply means that the company will have to conduct a market research relating to the kind of products and services the company offers (Adams, 2000). Well carried market research will involve the number of participants in the exercise and thus it will be showing the potential customers who will use the products or services when it is launched. This method involves experts who carry general opinions and then the experts will compile that data so as to forecast on the trend. For example, the company may look at the competitive advantage over other companies, as well as corporate governance among other aspects. Quantitative model do away with human analysis but solely depends on the data. This method of forecasting also involves other variables which are predicted sales, the gross domestic products among others which are predicted for long term goals (Lawrence, 2010). Quantitative model involves the following tools. The approach depends on some indicators like unemployment rate, and the gross domestic product among others in the company. To get the indicator then a comparison and the

Orem's theory of self-care in the maternity department Essay

Orem's theory of self-care in the maternity department - Essay Example As the essay declares the subject of short study here is, ‘The concept of Self-Care’ in nursing practice as envisaged in the maternity department of a hospital. It will be argued that the Praxis of Self-Care could greatly improve the rehabilitative role of nurses by positively influencing an individual’s self-care agency; which is the power component of self - care behavior, as according to Dorothea Orem’s Theory. This paper discusses that the term ‘Self-Care’, is familiar through Orem’s Self-Care Deficit Theory of nursing. Orem’s theory is composed of three related theories: the theory of Self-Care, the theory of Self-Care Deficit and, the theory of Nursing Systems. Orem’s theory views the individual as a self – care agent with especial needs. When ‘self-care’ is practiced it enhances health and well-being being. There is a visible link between responsibility and self-care; Self-care can be stated as a self-initiated, deliberate and purposeful activity linked to health and well-being. Pertinent action is performed to meet the therapeutic self-care demand arising out of known needs for care. This varies from time to time, as required by the various stages of life-cycle, of the individual person. The non-fulfillment of this demand, gives rise to a self-care deficit, which denotes the need for nursing. The decision to provide self-care is tak en jointly by the patient and the nurse. Herein the nurse plays a pivotal part in the influence of the patient.

Bees Disappearance Essay Example for Free

Bees Disappearance Essay A new federal report blames a combination of problems for a mysterious and dramatic disappearance of U. S. honeybees since 2006. The intertwined factors cited include a parasitic mite, multiple viruses, bacteria, poor nutrition, genetics, habitat loss and pesticides. The multiple causes make it harder to do something about whats called colony collapse disorder, experts say. The disorder has caused as much as one-third of the nations bees to just disappear each winter since 2006. Bees, especially honeybees, are needed to pollinate crops. The federal report, issued Thursday by the Agriculture Department and the Environmental Protection Agency, said the biggest culprit is the parasitic mite varroa destructor, calling it the single most detrimental pest of honeybees. The problem has also hit bee colonies in Europe, where regulators are considering a ban on a type of pesticides known as neonicotinoids that some environmental groups blame for the bee collapse. The U. S. report cites pesticides, but near the bottom of the list of factors. And federal officials and researchers advising them said the science doesnt justify a ban of the pesticides yet. May Berenbaum, a top bee researcher from the University of Illinois, said in an interview that she was extremely dubious that banning the pesticide would have any effect on bee health. She participated in a large conference of scientists that the government brought together last year to figure out whats going on, and the new report is the result of that conference. Berenbaum said more than 100 different chemicals — not just the pesticides that may be banned in Europe — have been found in bee colonies. Scientists find it hard to calculate how they react in different dosages and at different combinations, she said. Some of these chemicals harm the immune systems of bees or amplify viruses, said Penn State University bee expert Diana Cox-Foster. At a news conference Thursday, Sonny Ramaswamy, a top USDA official, said the scientific consensus is that there are multiple factors and you cant parse any one out to be the smoking gun. USDA bee researcher Jeff Pettis also cited modern farming practices that often leave little forage area for bees. Dave Gaulson of the University of Stirling in Scotland, who conducted a study last year that implicated the chemical, said he cant disagree with the overall conclusions of the U.  S. government report. However, he said it could have emphasized pesticides more. The environmental group, Pesticide Action Network North America blasted the federal government for not following Europes lead in looking at a ban of certain pesticides. Pollinators, like honeybees, are crucial to the U. S. food supply. About $30 billion a year in agriculture depends on their health, said Ramaswamy. Besides making honey, honeybees pollinate more than 90 flowering crops. Among them are a variety of fruits and vegetables: apples, nuts, avocados, soybeans, asparagus, broccoli, citrus fruit and cranberries. About one-third of the human diet comes from insect-pollinated plants, and the honeybee is responsible for 80 percent of that pollination. It affects virtually every American whether they realize it or not, said EPA acting administrator Bob Perciasepe. Zac Browning, a fourth-generation commercial beekeeper who has hives in Idaho, North Dakota and California, said the nation is on the brink of not having enough bees to pollinate its crops. University of Maryland entomologist David Inouye, who was not part of the federal report, said he agrees that there are multiple causes. Its not a simple situation. If it were one factor we would have identified it by now, he said. Inouye, president-elect of the Ecological Society of America, said the problems in Europe and United States may be slightly different. In America, bee hives are trucked from farm to farm to pollinate large tracts of land and that may help spread the parasites and disease, as well as add stress to the colonies, while in Europe they stay put so those issues may not be as big a factor. At the news conference, Berenbaum said theres no single solution to the U. S. bee problem: Were not really well equipped or even used to fighting on multiple fronts.

The General Environment Consists Of Six Segments Marketing Essay

The General Environment Consists Of Six Segments Marketing Essay Telecom Corporation of New Zealand Limited Telecom is a  company based on media and telecommunications industry offering telecommunications and information, communication and technology (ICT) services in New Zealand and Australia. The company has a headcount of about 8297 employees as of 2011 (Annual report of Telecom New Zealand, 2011).Telecom Corporation of New Zealand Limited is the largest telecommunications service provider in New Zealand providing consumers and business people with a wide range of products and services. Telecom operates under the following business units: Telecom Retail , Gen-i, AAPT, Telecom New Zealand International, Chorus and Technology shared services (Annual report of Telecom New Zealand, 2011). Today, Telecom plays a significant marketing leader role by owning more than one million fixed line customers and over two million mobile connections in the New Zealand telecommunications market (Annual report of Telecom New Zealand, 2011). However, the companys total operating revenues and total gains for the financial year 2011 (ending June 2011) is about NZ$ 5122 million, a decrease of 2.8% over the financial year 2010 (Annual report of Telecom New Zealand, 2011). Environmental factors General Environment Analysis According to Hanson, Hitt, Ireland Hoskisson (2011), the general environment consists of six segments: Demographic segment Telecoms major operations are carried out in New Zealand and Australia which contributes to very less population globally. The region consists of people from different ethnic groups like Maoris, Europeans, Asians and Pacific Islanders with lots of immigrants from different parts of the world. The major source of income is through salaries and wages; others include interests, investments and self-employment. Economic segment The New Zealand economy is suffering a quite slow recovery with the GDP result growing by 0.3 % in December 2011 quarter (New Zealand Statistics, 2012). Furthermore, the companys revenue decreased in the year 2011 which is not a good thing in the industry. It also depends on the nations economic condition in the World Market. Sometimes recessions may also affect the companys performance. Political/legal segment Telecom has its own governance objectives, policies, taxation laws and regulations for its employees. It should also be following the Telecommunication Act set by the Government. Furthermore, the Telecommunication Amendment Act in New Zealand will simplify telecommunications regulation and increase the marketing competition within the telecommunication service industry in New Zealand (Telecom New Zealand, 2012). The firm should also be following the Human Rights Act and Employment law for the firms employees. Legal proceedings are carried out for violation of laws and regulations. Socio-cultural segment Telecom consists of diverse set of people in the workplace who helps in the companys success in the Global Market. The employees face a lot of challenges in order to meet the Companys goals and objectives. It has a wide range of diversity programs such as Leadership programmes, Global Women programmes and flexible working policies (Annual report of Telecom New Zealand, 2011). Telecom foundation was recently started to do charity and community works. The firm also have concerns about New Zealands environment (Telecom New Zealand, 2012). Technological segment Since Telecom being a part of the telecommunications Industry, there are a lot of new technologies and innovations being created at a very fact pace. So the company must learn the new technology very fast so as to adopt the new technology ahead of its competitors. The company has also shown interest in the new technology called the Ultra Fast Broadband initiative which is a new technology for faster broadband connections (Telecom New Zealand, 2012). There is also a more focus of globalisation of technology and internet enabled services. Global segment Telecom is company that is based in New Zealand and Australia. So the company is not globally attracted. It should expand the organisation globally so that it can gain a competitive advantage over its competitors when they have a global presence in the industry. Globalisation always helps in creating opportunities and challenges for the firm which makes them more successful in the industry. Industry Environment Analysis According to Hanson et al (2011), the five forces of Industry environment consists of : Threat of new entrants Entry into the telecommunication industry requires a huge capital because they need to build a great infrastructure within New Zealand. The threat of new entrants will be lower in the industry because they have to compete with its well-established competitors. However due to lower switching costs between service providers, the new entrant may have an opportunity in the existing market share when their services are cheaper than the existing competitors. The government policies are also liberalized for entry in the telecommunication industry which is an added advantage. Overall, the threat of new entrants in the telecommunication industry is medium. Planning Process and Strategies From the above General Environment we can find factors that influence and also affect the industry in the form of opportunities and threats. These factors mainly depend on the competitiveness, market share, substitute products, supply and demand. Opportunities can be listed as: Growing broadband market with the introduction of ultra-fast broadband initiative in New Zealand which helps the company to gain more customers. Mobile data services are being used more these days as people tend to use mobile for browsing the internet. Increasing growth of mobile payment service which is an easy and a convenient way to do transactions due to more use of Smartphones. Threats can be listed as: Globalisation of the company is important to survive in the industry Legal proceedings of the company involves more legal costs Intense competition among the competitors acts as a threat in the industry Team Structure And Dynamics The industry consists of only a few potential competitors which is an advantage for the company. But there are also new competitors and also the threat of new entrants which lowers the companys market share in the industry. The company has its own substitute products due to advancements in technology and thus when people want to switch from fixed to mobile connection; the company eventually retains its new customers. When the company is updated in the technological world, it will eventually gain new customers and also retain its own customers as well. Thus the bargaining power of suppliers is relatively high. Bargaining power of buyers The industry is characterised by large number of potential buyers who are independent in choosing their own service provider. Customers tend to choose their service provider based on the companys customer service and price range. So the customers gain an advantage to switch to other service providers when required which decreases the suppliers power. However when the buyers are in a contract period, the switching costs are relatively high which is an advantage to the suppliers. Thus the bargaining power of buyers is medium. Threat of substitute products Telecom is a part of the telecommunication industry and it has its own substitute products as the company has both fixed and wireless connections. Since the substitute products are there within the own company it is not found to be a key issue for the company. Thus overall the level of threat of substitute products is relatively low. Rivalry among competing firms The New Zealand Telecommunication Industry has its major competitors like Vodafone, Telecom, Telstra clear and 2degrees. The rivalry among these competitors is relatively high because of their different approaches in the industry. Vodafone is said to be the major competitor of telecom because of its global presence in the industry. 2degrees has also set a mark in the industry due to its cheaper prices and quality plans. Thus the rivalry among the competing firms is said to be high. Competitor The key competitors of Telecom across various business units are Telstraclear, Vodafone Group PLC, Hutchison Telecommunications (Australia) Limited, AirNet Systems, Inc, Woosh Wireless, CallPlus Ltd, Hewlett-Packard Company, IBM Corporation, Singapore Telecommunications Limited (SingTel), Two Degrees Mobile Limited, Orcon Internet Limited. Though Telecom is one of the largest communication industries in New Zealand, there are also potential threats because of its competitors. Vodafone is the largest mobile phone operator in New Zealand which is mainly because of its global presence in over 30 countries. 2degrees is also gaining advantage with low call rates and innovative plans. So Telecom should gain competitive advantage by expanding the organisation globally by providing quality service and cheap products. Leadership: Telecom following the democratic leadership. Democratic leaders make the final decisions, but they include team members in the decision-making process. They encourage creativity, and team members are often highly engaged in projects and decisions. There are many benefits of democratic leadership. Team members tend to have high job satisfaction and are productive because theyre more involved in decisions. This style also helps develop peoples skills. Team members feel in control of their destiny, so theyre motivated to work hard by more than just a financial reward. Because participation takes time, this approach can slow decision-making, but the result is often good. The approach can be most suitable when working as a team is essential, and when quality is more important than efficiency or productivity. The downside of democratic leadership is that it can often hinder situations where speed or efficiency is essential. For instance, during a crisis, a team can waste valuable time gathering peoples input. Another downside is that some team members might not have the knowledge or expertise to provide high quality input. Conclusion: Telecom has a leading marketing position within the highly competitive marketplace. Currently the management of Telecom is facing some strategic issues in telecommunication industry. Some of the key issues are the Ultra Band Broadband initiative introduced by the New Zealand Government which is said to be the future of broadband connections in New Zealand. So Telecom should be very keen in providing better service to the customers with the new broadband initiative so as to gain a competitive advantage over other competitors. The companys profitability and revenue has also decreased in the financial year 2011 which is considered to be an issue in the market value of the company, so the company should try to gain more profits and revenues in the future. The company should also change its marketing strategies so that it can attract more customers in the future. With lots of new technologies being innovated the company can use these technologies to market their products and services so as to create positive market position in the industry.

The Biopharmaceuticals An Overview Biology Essay

The Biopharmaceuticals An Overview Biology Essay Biopharmaceuticals are defined as proteins and nucleic acids which are used for therapeutic purpose. These are high molecular weight substances prepared by biotechnological means and genetically engineered. Due to their complex structure and intricate molecular composition it is very difficult to characterize and formulate such products. Most of these products are derived from biological species and genetically engineered to produce a potent compound [1-3]. Humulin (biosynthetic recombinant human Insulin) was the first biopharmaceutical product developed by Genentech but licensed and marketed by Eli Lily and Company in 1982. In the modern era biopharmaceutical products have become a major facilitating reason of technological changes in health care sector, causing extraordinary benefits for patients, cost challenges for consumers, and profits for market shareholders.[4] Over the last decade biopharmaceutical market is the fastest growing segment in the pharmaceutical organizations. After post-recession period vigorous advancement has been seen in this area. It has been reported that approximately 40% of total pharmaceutical RD investment is occupied by biopharmaceutical products amongst which, monoclonal antibodies and product produced by recombinant DNA method are the most prevalent one.[5,6] Proteins with different amino acid sequences are the primary structure of such products. For determining the biological activity of a protein it is necessary to study its three-dimensional structure. The structure of protein is generally divided into four categories i.e. primary, secondary, tertiary and quaternary (fig. 1). The primary structure is the sequence of amino acid residues which folds and stabilized by the formation of hydrogen bonds with subsequent molecules in the polypeptide chain to produce an  ÃƒÅ½Ã‚ ± helix,  which is a spiral, rod-like st ructure, or a  ÃƒÅ½Ã‚ ² sheet,  a planar structure. This structure resembles to the secondary structure of proteins. The tertiary structure is a three-dimensional arrangement which gives an overall conformation of a polypeptide chain. Through hydrophobic interactions between the non-polar side chains and disulfide bonds, this tertiary structure is stabilized. A quaternary or multimeric protein contains two or more polypeptide chains, held together by non-covalent bonds.[7] fig 1. Structure of protein. Because of their unique physicochemical characteristic it is very hard and challenging to formulate biopharmaceuticals as products with therapeutic effects and storage characteristics. Meanwhile their formulation is in many ways different from conventional low-molecular drug formulation. Despite of such facts biopharmaceuticals gains lots of attention in the modern era of drug formulation. In the recent reviews it has been discussed that around 400 biotechnology-based medicinal and therapeutic agents are either registered or in the clinical trials are reviewed by the regulatory bodies. These agents are helpful in treating many life threatening diseases some of them are cancer, infectious diseases, autoimmune diseases, and AIDS/HIV. Some of the agents which are already in the market are monoclonal antibodies, recombinant hormones, cytokines, vaccines, recombinant blood factor, and therapeutic enzymes.[5] Discussion Biopharmaceutical market In 1970, discovery of recombinant DNA technology and monoclonal antibodies lead to initiate the development of biopharmaceutical industries. A substantial growth from $8 billion in 1992 to $149 billion in 2010 quenched the thirst of investors towards the biopharmaceutical industry. It is expected to reach $239 billion by 2015 with a growth rate of 9.9% annually. There are more than 400 Biotech drugs and vaccines are scrutinized under clinical stage, targeting more than 200 diseases. Meanwhile a large number of the population is now taking benefits from a number of biotechnological innovations like recombinant protein-based products e.g. monoclonal antibodies and some large molecule prescription drugs, which include hormones and vaccines. Table 1 illustrates some of the leading biopharmaceutical therapy classes by size worldwide in 2002. In 2008 approximately 39%, among the top 10 drugs sold globally, are biopharmaceuticals and is expected to rise to 79% of the top 10 drug sales by 20 14.[8] Table.1: Leading biopharmaceutical therapy classes by size worldwide 2002. Source: IMS MIDAS December 2002. However after the post recession period, fundings over health care and other sector is reduced which impede the growth rate of pharmaceutical industries up to significant extent. Although biopharmaceutical global sales thrive to attain high numbers in the global health sector. Biotechnological based products have generated $229 billion revenue in 2012 with an annual growth rate of 10.4%. Meanwhile the major focus of pharmaceutical organizations is on biopharmaceutical vs. Small molecule drugs which enables to allocate high funding towards this area. This may be due to very less generic biosimilar products available in the market. In year 2009 there are total 18 biopharmaceutical products are approved by US FDA which is higher than the previous years i.e. 11 in 2008 and 10 in 2007. In a report of Battelle Technology Partnership Practice, it was estimated that the overall impact of biopharmaceutical sector on the US economy is $917 billion. These companies are making alliances with oth er essential services such as computing and information, clinical trial and regulatory support services, technologies, manufacturing and equipment, and transportation and logistics providers.[9-11] Types of Biopharmaceuticals Cytokines Cytokines are a diverse group of non-antibody intercellular signalling regulatory proteins i.e. glycoprotein and low molecular weight peptides produced in very little amount inside the body. They function as a mediator for communication between various cells and induce certain response by binding to specific cell surface receptors which results in triggering various intracellular signal transduction mechanism. There are over 80 sub class of cytokines have been found. Some of these are categorized in table 2. They play an important role in coordinating embryonic development, cell growth and maturation, wound repair and healing, the immune response including acute phase reactions and septic shock, and new blood vessel formation. Cancer is among the major class of disease which is thoroughly scrutinized by the researchers with an emphasis on cytokines. However cytokines also play a vital role in mediating signalling response to systemic inflammation which tends to regulate specific neur onal network to induce sickness. Some animal studies reveal the role of cytokines in situations characterized by abnormal sleep, with emphasis on the pathogenesis of symptoms and consequences of OSAS (Obstructive sleep apnoea syndrome). Cytokines interact with specific cells via (1) intracrine, in which both cytokine and receptor remain within the cell (rare); (2) autocrine, where a cytokine acts on the receptors of the same cell it is produced; and (3) paracrine, where the cytokine from one cell type interacts with receptors on other cell types.[12-16] Table 2: categorization of cytokines. There are various cytokines products available in the market and some of them are reviewed under the clinical phase for example Interleukin-2 (IL-2) aldesleukin (Proleukin), for treating renal cell carcinoma is approved by FDA. IL-1 blocker, anakinra (Kineret) and rilonacept (Arcalyst) are used for the treatment of rheumatoid arthritis and cryopyrin-associated periodic syndromes respectively.[1] Enzymes Enzymes are complex molecules produced by living cells. They increase the rate of chemical reaction without even showing their own effect in the process and hence act as a catalyst in living organisms.[17] Because of their reaction specificity, catalytic efficiency and ability to operate under mild condition of temperature and hydrogen ion concentration they are preferred as a novel class of therapeutic agents. Despite of their therapeutic role enzyme endures significant importance as a replacement therapy in many genetic disorders. However there are some disadvantages as well associated with their use such as, their parental administration required extensive purification to remove contaminants. They are also very costly to prepare and due to their large molecular structure they have limited distribution in the body. As they are proteins hence when administered inside the body act as antigen to the host cell.[18,19] Enzymes are categorized under six major classes i.e transferases, lysases, hydrolases, isomerases, ligases, and oxidoreductases. The potential utility of enzyme as pharmaceutical was noted many decades ago. However most of the enzyme therapies are used to treat functional defects. Activase ® (alteplase; recombinant human tissue plasminogen activator), is the first recombinant enzyme drug which was approved by the Food and Drug Administration in 1987. Pulmozyme ® (Dornase alpha), a recombinant DNAse I that digests DNA in the mucous secretions in lungs, used to treat cystic fibrosis. Adagen ® (pegadamase bovine), is the first marketed product as enzyme therapy for the treatment of SCID (severe combined immunodeficiency disease).[20] Hormones Hormone is characterized as an important group of regulatory molecule which is synthesized in an organ or in tissue and then secreted into circulatory system where it affects respective organs whose cell bears an appropriate receptors. They are chemical messengers either small or a large macromolecule and are fairly defined as endocrine hormones. Approximately all endocrine hormones possess therapeutic importance and hence subsequently used by the researchers e.g. insulin(Insugen ®, Humulin ®, Novolin ®), human growth hormone (Ascellacrin ®, Crescormon ®), glucagon, and the gonadotrophins.[1] Antibodies: Antibodies or immunoglobulin are proteins produced, as an immune response, through white blood cells when a foreign particle or antigen intrudes inside the body. There are five classes of immunoglobulin IgE, IgM, IgG, IgD, and IgA. Amongst them IgG is the most common as a biopharmaceutical agents. A more specified term i.e. monoclonal antibodies (mAb  or  moAb) are the novel class compounds that are first developed in mid 1970s by kohler and Milstein, who successfully fused immortal cells with antibody- producing B lymphocytes. This fusion results in a hybrid which is stable, cancerous, antibody- producing cells. These are referred as hybridoma cells which unveil great source of monoclonal antibody. mAb identify antigens on a particular foreign body very specifically. mAbs are categorized under four groups according to their source: murine (derived solely from mice), chimeric (mixture of murine and human sequences), humanised (contain over 90% human sequences) and fully human.[8, 17] In 1986, Murobmonab (OKT3), a murine antibody, is the first monoclonal antibody tested as a therapeutic in humans. However it fails to produce a substantial response in the transplantation rejection patients because of production of anti-murine antibody.[20] Monoclonal antibodies are the fastest growing therapeutic class in the field of biopharmaceutical market. The market of monoclonal antibodies crosses the mark of $30 billion in 2011. Infliximab (Remicade) is the top selling monoclonal antibody in 2002 which was developed by Centocor and is marketed by Centocor and Schering-Plough for the treatment of rheumatoid arthritis (RA) and Crohns disease. Rituximab (Rituxan), developed by Genentech and IDEC and marketed by Genentech, IDEC and Roche, for the treatment of non-Hodgkins lymphoma, is the second largest selling monoclonal antibody.[21] Vaccines: Vaccines are antigenic proteins which are either partial or modified form of bacteria, viruses and toxins which causes certain diseases against which vaccine protects. The antigenic property of vaccines is altered from its original form by certain processes such as utilizing attenuated viruses, inactivated viruses, part of a virus or bacteria and toxin produced by bacteria; hence they lack ability to cause disease although, endures ability to produce an immune response.[22] Vaccines are the only known prophylactic approach which are commonly available to cure many infective diseases. Vaccines cover the global market share of $ 3 billion annually. Government health agencies run different immunization programs which alleviate the risk of many infective disorders. However, there are approximately 15 million people die every year from certain infectious diseases that can be cured by vaccination process. Pharmaceutical and biopharmaceutical industries seek great potential in this area but the use is limited because of their high production cost, delivery and distribution problems. Vaccines may contain animal derived products such as Bovine serum albumin or fetal calf serum or human derived product for example using cell lines of human tissues. However in recent years transgenic and recombinant plants are also utilized for the production of vaccines.[12,23,24] There are different vaccines available in the market for many infectious diseases such as poliomyelitis, cholera, diphtheria, tetanus, hepatitis B, hepatitis A, measles, meningitis etc. For hepatitis B virus some examples are Baraclude (Entecavir ®), Adefovir dipivoxil (Hepsera ®), Lamivudine (Epivir ®-HBV, 3TC), Alfa Interferon (Intron ® A, Infergen ®, Roferon ®).[1,25] Antisense drugs: Antisense compounds are non-coding strand of messenger RNA(mRNA), which hybridize with mRNA and inactivates the ability of genes to produce the protein for which it holds the recipe.[26] They do not alter human gene causing variation in human genetic information. It was first developed in 1978 using a string of DNA nucleotide which binds with messenger RNA and block its function. These drugs are designed to treat a wide range of diseases such inflammatory, infectious, cancer and cardiovascular diseases. Fomiversen was the first antisense drug approved in 1998 for the treatment of cytomegalovirus retinits in AIDS patients. These are categorized under three sub-classes i.e. antisense oligonucleotides(ASONs), ribozymes and RNA interference(RNAi). Affinitak, manufactured by ISIS pharmaceuticals and Eli Lilly, is used for the treatment of non-small-cell lung carcinoma(NSCLC). There are certain antisense compound are under review by health agencies for their therapeutic efficacy towards ma ny anomalies[27,28] Peptide therapeutics: Peptides are polymers having one or two amino acids linked with amides and are chemically synthesized by using liquid phase or solid phase synthesis. Their chemical synthesis is preferred over biosynthetic approach because it facilitates the conjugation or incorporation of small molecules and non-natural amino acids. This approach reveals the potential of such molecules as cytotoxic agents for antitumor therapy. Peptides with non-natural opens up the possibility for greater chemical diversity, analogous to small-molecule medicinal chemistry approaches for developing high-af ¬Ã‚ nity, highspeci ¬Ã‚ city molecular recognition. Cationic antimicrobial peptides (CAMPs) and peptidoglycan recognition proteins (PGRPs)are developed from the effectors of innate immune response in eukaryotes during their defense mechanism. However there are not many products of peptides found in the market but researchers are trying to develop some therapeutic peptides and proteins with significant effect towards certain diseases. Nesiritide (Natrecor, Noratak) is produced by Johnson Johnson2001, Teriparatide (Forteo) is developed and marketed by Lily in 2002 Enfuvirtide (Fuzeon) is manufactured by Trimeris 2003.[29-31] Challenges associated with biopharmaceutical products: Biopharmaceutical products such as monoclonal antibodies, vaccines, certain hormones, and cell therapies are rewarded as some of the most promising innovation in the field of medicine and health. However there are certain risk and challenges associated with such products which hamper their performance. One of the major challenges is the purification of proteins although it can be achieved by various processes but still purification of such compound is very critical hence requires a lot of attention during manufacturing. Next generation pharmaceutical.[32] However the whole process is carried out under two phases i.e. upstream and downstream regulation. Immunogenicity associated with some of these proteins is also a major concern for biopharmaceutical agents. A repeated injection of human protein may affect the immune tolerance towards self- antigen, leading to humoral response.[33]   Biopharmaceutical products require greater attention, process level as well as monitory level, in the development phase of the drug discovery process it requires approximately $200 million to develop a biopharmaceutical product hence the risk associated with their failure during development stage is increased. Apart from purification and immunogenicity some other issues also make some impact during their development such as government regulations which influence the cost of such products. As discussed earlier it takes a large amount of money to develop such agents hence companies also compensate their development cost and earn profits from their products, ones marketed, which exponentially increases the cost of the drugs. Last and one of the most important risk associated with such products is the introduction of biosimilar products. Biopharmaceutical market is growing very fast, the initial compounds of the first generation are now coming to an end. The expiry of the patents opens the market for generic products which not only influence the established market of some very popular brands, it also forms a milieu of competition to sell the products at cheaper rates which is compensated by their quality.[34] Conclusion Biopharmaceutical products are one amongst the novel class of therapeutic compounds. These are medical agents obtained from biological sources and some special one are manufactured by biotechnological means. They are cellular products, therapeutic proteins, vaccines, gene therapy products and plasma blood product derivatives. Erythropoietins, insulins, and monoclonal antibodies, are some of the leading biopharmaceutical products available in the market hence biopharmaceutical companies are now focusing on their use in long-term conditions such as cardiovascular disease, diabetes and asthma. The blockbuster sales of some existing biopharmaceutical products accompanied by the tremendous innovation and a plethora of pipeline products demonstrate the vigorous growth in the biopharmaceutical market in upcoming years. This significant growth is supported by some of the key segments of the field like monoclonal antibody and vaccines. In addition approaches like gene therapy and peptide ther apeutics holds enormous potential for some life threatening anomalies and the combined approach of proteomics, genomics and biotechnology is predicted to empower the most part of the healthcare sector in the upcoming days.

William Faulkner :: essays research papers

Biography on William Faulkner William Faulkner was born in New Albany, Mississippi on September 25, 1897 and then moved to Oxford, Mississippi with his family at the age of 5. Most of the novels written by William Faulkner take place in the area in which he himself was born and raised. He renames Oxford and calls this place Jefferson, Mississippi. Faulkner is a contemporary American author who has achieved greatness as an author. He is already considered to be one of the world’s greatest novelists and has been awarded with the Nobel Prize for literature in 1949. This is quite an achievement as it is the highest prize that can be awarded to an author. Of all of Faulkner’s achievements, "The Sound and the Fury" is considered to be one of his greatest novels. Faulkner was part of a distinguished family in Mississippi. His name was originally spelled Falkner. The "u" was added by mistake when his first novel was published and William Falk ner decided to retain the spelling of "Faulkner". The most distinguished member of William Faulkner’s family was his great-grandfather, Confederate Colonel William Cuthbert Falkner. The Colonel first moved to Mississippi in the early part of the 19th century from his home South Carolina. Faulkner uses Colonel Falkner as a character in his novels named Colonel John Sartoris. Colonel Falkner had a notable career as a soldier in the Civil War and the Mexican War. Colonel Falkner was also a writer like his great-grandson and published one of the nation’s best sellers called "The White Rose of Memphis". Before being assassinated by a former partner in 1889, Colonel Falkner also took the time to build a railroad and run for public office. Faulkner received his initial education in Oxford, however he dropped out of high school in 1915. He attempted to join the U.S. Army but was rejected for pilot training so he joined the Canadian Royal Air Force in 1918 but the war ended before he spent any time in service. After the ending of the war, Faulkner took some classes at the University of Mississippi and spent a short time working at the university post office. The majority of his education was due to his promiscuous time he spent reading. Faulkner had started writing poetry as a young schoolboy. In 1924, he used his own financial resources and published a collection of poetry called "The Marble Faunn". William Faulkner :: essays research papers Biography on William Faulkner William Faulkner was born in New Albany, Mississippi on September 25, 1897 and then moved to Oxford, Mississippi with his family at the age of 5. Most of the novels written by William Faulkner take place in the area in which he himself was born and raised. He renames Oxford and calls this place Jefferson, Mississippi. Faulkner is a contemporary American author who has achieved greatness as an author. He is already considered to be one of the world’s greatest novelists and has been awarded with the Nobel Prize for literature in 1949. This is quite an achievement as it is the highest prize that can be awarded to an author. Of all of Faulkner’s achievements, "The Sound and the Fury" is considered to be one of his greatest novels. Faulkner was part of a distinguished family in Mississippi. His name was originally spelled Falkner. The "u" was added by mistake when his first novel was published and William Falk ner decided to retain the spelling of "Faulkner". The most distinguished member of William Faulkner’s family was his great-grandfather, Confederate Colonel William Cuthbert Falkner. The Colonel first moved to Mississippi in the early part of the 19th century from his home South Carolina. Faulkner uses Colonel Falkner as a character in his novels named Colonel John Sartoris. Colonel Falkner had a notable career as a soldier in the Civil War and the Mexican War. Colonel Falkner was also a writer like his great-grandson and published one of the nation’s best sellers called "The White Rose of Memphis". Before being assassinated by a former partner in 1889, Colonel Falkner also took the time to build a railroad and run for public office. Faulkner received his initial education in Oxford, however he dropped out of high school in 1915. He attempted to join the U.S. Army but was rejected for pilot training so he joined the Canadian Royal Air Force in 1918 but the war ended before he spent any time in service. After the ending of the war, Faulkner took some classes at the University of Mississippi and spent a short time working at the university post office. The majority of his education was due to his promiscuous time he spent reading. Faulkner had started writing poetry as a young schoolboy. In 1924, he used his own financial resources and published a collection of poetry called "The Marble Faunn".

The Beauty of Dulce et Decorum est Essay -- Dulce et Decorum Est Essay

The Beauty of Dulce et Decorum est    Owen's terrific use of diction brings the poem Dulce et Decorum Est to life. Vivid imagery is prevalent all throughout the poem. His tone is of depression, lack of hope and of course sadness and it reveals his message without writing pages of verse. He accomplishes his message very quickly in the poem, and makes the reader feel like they are actually experiencing what the narrator is going through. Through vivid imagery and compelling metaphors, the poem gives the reader the exact feeling the author wanted. The poem "Dulce et Decorum Est," an anti-war poem by Wilfred Owen, makes great use of various poetic skills. This poem is very effective because of its excellent manipulation of the mechanical and emotional parts of poetry. Owen's use of exact diction and vivid figurative language emphasizes his point, showing that war is terrible and devastating. Furthermore, the utilization of extremely graphic imagery adds even more to his argument. Through the effective use of all three of these tools, this poem conveys a strong meaning and persuasive argument. The poem's use of excellent diction helps to more clearly define what the author is saying. Words like "guttering", "choking", and "drowning" not only show how the man is suffering, but that he is in terrible pain that no human being should endure. Other words like writhing and froth-corrupted say precisely how the man is being tormented. Moreover, the phrase "blood shod" shows how the troops have been on their feet for days, never resting. Also, the fact that the gassed man was "flung" into the wagon reveals the urgency and occupation with fighting. The only thing they ca... ...orum est pro partria mori" means: "It is sweet and becoming to die for one's country." Owen calls this a lie by using good diction, vivid comparisons, and graphic images to have the reader feel disgusted at what war is capable of.he tries to tell us that war is an ugly, brutal and nightmarish business, and not a glorious affair that society seems to beilieve. Most will not have seen the war of Owen's experience. But through his vivid words, his gruesome portrayal we know that we do not wish to .Poetry does not have to be pretty, however some poets do not seem to realize this fact. The language chosen in many poems about grisly subjects flows beautifully and elegantly from the page, leaving one feeling less pain about the subject matter of the poem than one really should. What is so beautiful about this poem is its ability to move the reader.

Kiss of the Spider Woman

In Manuel Puig’s novel Kiss of the Spider Woman, Molina and Valentin use fantasy as a way of escapism. Firstly, Molina uses the films he tells in the cell to escape his unfavorable and lonely life by creating a preferred reality through the fantasy he creates in them. Secondly, the setting of the cell itself provides Molina with a sanctuary from the outside world, allowing him to escape from the gender roles in which he is confined in and fantasize about taking on the feminine role with Valentin through the isolation of jail.Lastly, in Valentin’s morphine-induced fantasy at the end of the novel, he can escape from the socially accepted stereotypical male gender roles and express his true feelings about Molina. Firstly, Molina uses the fantasy presented in the films he reiterates as a way to escape from the harsh reality of the real world, creating his own, more favourable one. This perspective can be seen throughout the novel, particularly in association with the strong romantic and feminine aspects displayed in the films.A film that allows Molina to escape the real world is told through his stream of consciousness in chapter five, which tells the love story between an unattractive maid and a young soldier, face scarred by the war. This film is very personal to Molina in two aspects. Firstly, it is told not aloud to Valentin, but inside his own head, and secondly, it features a protagonist who is an outcast to society who nonetheless finds love. It is told through the first person perspective of the maid, and the use of personal pronouns draw a connection between the characters of Molina and the maid.This parallel characterization is heightened through the maid’s casual and repeated reference to herself as an â€Å"ugly girl† (100), mimicking Molina’s expressions of self-deprecation through belittling diction. He is constantly using words like â€Å"revulsion† (260) and â€Å"disgust† (262) to describe himself wi th, and he even interjects the film to recount the judge’s description of him as â€Å"the worst, a revolting fag† (106). It is clear that Molina, a gay man living in a homophobic country of machismo men feels like an outsider with a lack of self worth.In the chapter three, Molina relates the story of his unrequited love for the waiter Gabriel: a heterosexual man who does not return Molina’s feelings. Molina is escaping from the bitter truth of his own love-less life and living through the fantasies he presents in the form of films: an outlet that allows him to experience a preferred and utopian reality. Puig’s purpose in drawing a parallel between the maid and Molina is to express Molina’s intense desire to find love and acceptance and suggest the eventuality this lies in Molina’s future, as it did for the maid.Through film, Molina can escape the bitter actuality of his own life into his own highly romantic and idealistic fantasies. Not onl y does Molina use fantasy in his stories as a way of escapism, through the isolation of their cell, Molina can escape from confining traditional gender roles and assume the feminine role with Valentin, a form of fantasy for him. Throughout the novel, it has been made clear that Molina identifies with women; even claiming â€Å"I want to be one† (19). Inside the cell Molina is able to escape from the prejudice experienced in his primarily homophobic country and don the feminine traits he associates himself with.Molina cares for Valentin when the latter becomes ill, indulging in a fantasy in which he is sympathetic, caring and maternal. For example: â€Å"But you have to wait for that, until you feel okay, and you can be sure that you only get half of that†¦Ã¢â‚¬  (156). It is obvious that Molina enjoys being subservient to Valentin. In a sense, Molina is not so much homosexual as he merely believes himself a woman. Indeed, he firmly believes in the stereotypical and tra ditional roles of men and women: â€Å"But if a man is†¦my husband, he has to give the orders, so he will feel right. That’s the natural thing, because that makes him†¦ the man of the house† (244).Molina’s identification of himself as female is what makes him subject to prejudice, such as the kind he experienced with the judge. Towards the end of the novel, Molina comes to the realization that his situation outside the jail cell will never change, and that the fantasy he is experiencing with Valentin will not last: â€Å"No, they’ll never change†¦Ã¢â‚¬  (215). Puig creates the irony that it is within the confines of prison that Molina feels the most free, and it is outside where he feels imprisoned. Inside the jail cell, Molina is able to escape the bleak future in which he foresees himself never fully being able to embrace his gender identity.The fantasy he is living with Valentin is an opportunity to live his life like a woman, free fro m prejudice and discrimination. Although it is mainly Molina who utilizes fantasy throughout the novel, in his stream of consciousness at the end of the novel, it is Valentin who escapes from the pain of real life and the confinement of the cell into a morphine-induced fantasy. In this dream-like state, Valentin, free from socially accepted gender roles, is able to express his true feelings and thoughts.At the beginning of the novel, Valentin’s only addition to the films appeared in blunt interruptions, often times closer to criticism of the films than positive contribution: â€Å"I don’t really get it, it’s very confusing the way you tell it† (12). As the novel progressed, and Valentin and Molina grew closer together, the dialogue between them became of greater significance, as Valentin let down his emotional guard. This emotional development culminated in Valentin’s expressive and out of character dream, full of vivid imagery, in which he can esc ape from the expectations of his gender, and express his true feelings, specifically towards Molina.The metaphor of Molina as the Spider Woman is epitomized in this chapter and through this image, Valentin can express his true feelings about him: â€Å"†¦so many threads that look like hairy like ropes and disgust me, even though if I were to touch them they might feel as smooth as who knows what, but it makes me queasy to touch them† (280). This represents Valentin’s initial unease about being intimate with Molina, but at the same time knowing that allowing someone into his personal life could potentially be gratifying.Being part of a revolutionary group, Valentin has been accustomed to severing personal relations that interfere with the cause. At the same time, he has been associated with having very masculine traits, even proclaiming: â€Å"I’m no woman† (38). By Valentin admitting both that he had sex with Molina, and that he â€Å"enjoyed itâ₠¬  (280) shows an immense diversion from his characterization at the beginning of the novel. In this fantastical state, he can escape from the traditional gender roles in which is perceived with and admit to his true sentiments.In conclusion, fantasy plays a very important role in terms of escapism for Molina and Valentin in the novel, both in terms of physical and physiological situations. Molina and Valentin experience three key escapist fantasies throughout the novel: Molina uses the fantasies in the films to escape his own disparaging life, Molina uses the setting of the cell itself as an escape for the gender roles he sees himself confined in in the outside world, and Valentin’s dream like fantasy allows him to express his true feelings and escape confining male gender roles.The purpose of these fantasies in Kiss of the Spider Woman is to provide the characters with an environment in which they can escape from the confines of their life and express their true feelings. Indeed, it is these fantasies that provide illuminating characterization and allow the reader to truly discern the nature of the characters of Molina and Valentin.Work Cited Puig, Manuel. Kiss of the Spider Woman. New York: Knopf, 1979. Print.

Dreaming has been there since the existence of man Essay

Dreaming is a communication mingled with the body, mind and the spirit in a imageic communicative environmental conjure of being. Our whizs being active fashion altogether the time, but at different states of disposition example, being alert, a light up, asleep, bored, day day stargaze parkway different waves in brain as far as the activity is concerned. The brain mind and spirit, while at break (when a person is sleeping) pass on check out and analyses m all things. This goes around emotions, ideas, thoughts, actions of a curt terms memory.This has a background of mortals past emotional state, and philosophy to cast it. The mind is overly processing spiritual data, beliefs, and any communication from the higher precedent (deity). All this information unitedly with subconscious of what people ever told you, is whencece(prenominal) process but without supervision by any person. All this information is put to rifleher by the mind in a form of Visual Screen play , as a mixture of many things much(prenominal) as sight, sound, emotion and imagined interactivity. This will in spades yield that which is referred to as dreams.Dreaming is considerably influenced by factors in a persons life and spirit, these influences bring some divisions that almost same as Gods. They argon usually categorized as standard, prophetic, nightmares and physical dreams. Standard dreams have a tendency of precognition happening randomly. fateful ones are those dreams carrying a message of what is dismission to happen in the future. It could be label for repentance, change of behavior or get prepared for an on coming disaster.Nightmares are sort of dreams that will frighten or upset the dream and it whitethorn induce some time before soulfulness gets back to sleep after having a nightmare. This is why dreaming is such a valuable thing because sometimes it may bring wealth, health, escape, spiritual gain etc. if dreaming is taken seriously, that is if peop le could get to concentrate and remember their dreams, there could be precise important messages hidden in the dreams. Dreaming may be important to remember and I will debate a few ways that would serve a person interested in mobiliseing their dreams do so.It is believed that if you get to bed a healthy relaxed person, pay attention to the master(prenominal) issues on the mind, give yourself a clue/idea to remember your dreams, plan to wake up slowly and peacefully such that you dont lost trend of the dream you may have had by rocketing out of the bed then most likely you will manage to recall the dreams you had in the night. It is in addition suggested that each a well balanced diet will help recall your dreams this is for the reason that all parts of the body including the brain is well nourished with a healthy diet. one time the person recalls the dream, it is important to analyze it. This fire be done by identifying the primary(prenominal) concept of the dream. This w ill involve pickings away all details and spirit at the dream as a whole. Concepts are for helping someone set out the bigger picture and since they are overly vague to use as a clear picture it is important then to take away details that erupt vague and be left with the very central picture. Once this is done then it is important to match the concept to a certain area of your life.Try to teach if there any element of your life that seems very precious to you, and then reflection if there is any possibility of it being damaged in any way as far as the dreams is concerned. If the effect is that there could be damage to your life, then re-examine the situation and the solution mogul just present itself to you. Dreaming and its moment are somehow related to animals and opposite universal symbols. Animals are sometimes symbolising our traits, good or bad. Vehicles are to signify the direction we are headed.Children may epitomise something new and joyous while habiliment may symbolize moods which are also related to attitudes we usually have. While dreaming about death may be common and scaring it is believed to bring changes and very hammy and major ones. It may symbolize confronting fright of change or fear of death. It could also signify threat. Another common dream is that involving people. This may be a symbol of a personal trait as long as the dream is not prophetic.

Network Consultation Proposal Essay

DesignIT is a vivid arts political party that is blow bingles stacking air and has recently purchased a new twist 56*36 space for the think of housing two full beat anatomyers and a receptionist. The new create has tetrad cubicles, bingle office, 1 horde room, one reception desk, and a conference room. DesignIT has already re turn up one net innkeeper (Microsoft IIS emcee), one File server (Microsoft innkeeper 2008), and one more Server 2008 (Small passeliness Server). As a earnings design consultant, I have been charged with the childbed of designing and configuring the interlocking for DesignIT. The trivial company has informed me that the engagement should complicate cardinal information processing systems, three printers, a Firewall, a radio converse net for portable thingummys, and a high gear move meshing mergeion. DesignIT has in any suit put across me that all the inter tieed devices and wiring, on with the speed should be able to wise crack the exceed performance. I pass on design a local anesthetic Area Network (local area engagement) for DesignIT, a Local Area Network (local area cyberspace) is a communicate of computers, and early(a) interlock devices such(prenominal) as printers which exchange entropy, and argon located under one roof.local area network networks are mostly apply in small arrangements or small businesses. The computers in a local area network communicate through and through protocols and administer data such as files and emails. every(prenominal) computer in a network is assigned a unique lucre Protocol (IP). When a computer communicates by sending a request to the LAN network, it is routed to a particular server that has the quest data. The server then communicates back to the IP address of requesting computer with the information that was pass along (Kenyon, 2002). on that point are three servers for DesignIT, the Web Server result be aim to connect the company to the prof its, and the File Server allow for be expendd for division-out while the Small worry Server ordain be employ as a Mail Server. Since DesignIT needs a network that incorporates six computers, three printers, and a wireless network, the network design should so happen uponseveral factors into consideration. These factors forget clash on the network costs, speed, root word, and functionality. When designing this Local Area Network (LAN) for DesignIT, there is as well as need to consider the network requirements.The network should integrate sound, video, synchronous, as well as asynchronous data. When designing the LAN network, the organisational goals of DesignIT should be factored in the LAN design. I leave similarly pay concern to network throughput, ocellus charges, certification department, and the integration of newer technologies in the future. When designing a LAN network, rough issues must be considered, one of these issues is the organizations short, medium, and long term goals. several(prenominal) factors to be considered include the network equipment, substance ab user applications, end-user equipment (workstations), and connectivity to the internet. The LAN network for DesignIT will include other network devices which include approach shotions, routers, firewall, and billets. Without these devices dialogue can non be possible from a computer to other in the LAN network. A router and switch are the most authoritative devices of a network. Networks which are well assemble and have a good infrastructure are helpful in upward(a) manageability, performance, reliability and reducing everyplaceall operate cost (Kenyon, 2002).To set up this LAN network for the DesignIT, the following are the computer hardware and software devices that I would utilize so as to design the LAN network for DesignIT. T1 Lines- This is a standard for data communication which was first developed in the 1960s. T1 lines offer a data rate of 1.544Mbps. I wil l utilize T1 nexus from Verizon to connect DesignIT to the internet. T1 lines are offer private vocalize and reliable data networking. A T1 line typically costs $ vitamin C0 per month. cisco Linksys Firewall- A firewall is a software or hardware network device that entertains launching and extroverted data communication through analyzing data parcel of lands and giving permissions whether to allow or not based on a set of rules. A firewall may in any case include a default gateway or a proxy server which helps to make network request on the behalf of a user. I will utilize Cisco-Linksys BEFSX41 EtherFast Cable/DSL Firewall Router (4-Port 10/100 Switch / VPN Endpoint) for this network.The device costs $150. LAN Switch- A LAN Switch performs the alike work as a hub keep out that, a switch does not dish out packets to every computer in the network like hubs. All the computers and computer devices will be connected to the switch by Ethernet cables. The LANSwitch costs $150. Li nksys radio set Router- A router is a network device that is used to connect two or more computer devices in a network. The Linksys radio producer router will be use to connect wireless devices the LAN network. The Linksys WRT54G Wireless Router that I will use in this case costs $150. Ethernet Cables- Ethernet Cables will be utilized to connect all the network devices in the DesignIT LAN network.They will connect routers, switches, computers, and printers in the LAN network. I will utilize CAT5 Ethernet Cables for this network. The Ethernet cables will cost about(predicate) $100 for DesignIT LAN network. ESET NOD32 Antivirus- an Antivirus is software that is used to prevent, detect, and remove malicious computer programs. ESET NOD32 Antivirus is a good choice since it besides acts against other types of malware such as worm, Trojan horses, backdoors, and spyware. The ESET NOD32 Antivirus 6 that I will utilize for this network costs $40 for subscription of one year.The building will share one internet participation (T-1 link from Verizon). This continuative will come to Web Server in the server room. This will be the access point of the LAN network of DesignIT. The T-1 link from Verizon will connect the company to the internet and can also be utilized to connect the LAN network to another LAN or WAN network in case the company decides to expand business in future. The T-1 link utilizes variety relay which will provide the building with high speed data connection amongst and among all users. This connection will also enable all computers to receive employ connection at a speed that every computer requires. This connection will also be low-priced for DesignIT since it is only if charged for the resources. It costs an bonny of $1000 per month. put relay is an patience standard engineering for accessing fast packet switched, cloud computing data networks (Bates, 2000). through and through T1 link DesignIT will use trope relay as an interface between data destination equipment such as routers, switches, and host machines such as servers. This technology will provide connectivity via logical conduct or permanent virtual racing circuit connections which will be deployed over dedicated access facilities and shared out on a high performance switching platform. This shared data platform and backbone makes ictus more efficient, such that allusers will receive better network throughput which is also cost effective. T-1 link technology is an added reward for DesignIT LAN network since it is flexible to use and an excellent platform for many application. Since doubled virtual connections are established over one physical access line, install Relay can reduce the weigh of customer premises router ports necessary for LAN applications. The number of private lines required to notice mesh connectivity and reliability can also be reduced.Frame Relay handles terminal to-host, LAN-to-LAN connections, or applications like imaging, e-mai l and graphic file transfers with equal simplicity. With all of these capabilities, Frame Relay is an excellent choice for DesignIT. I will configure a crystallize C network for DesignIT with an IP of 192.168.0.0/16. There will only be one subnet for this network. I have selected a household C network because it exhibits the ability to assault spamming of sites located on the same server. hunt club engines have removed linking power from one site to the other in case they are on the same partitioning C IP. I will take network gage measures so as to implement the best security for DesignIT. The security will be designed in respectfulness to the user group in question, this means that the two designers will share different user groups with the receptionist if need be. I will implement access control measures such as access logs so as to manage what each user should have access to in regard to the organizational policies and procedures.I will also install ESET NOD32 Antivirus in the Small Business Server. The Cisco Linksys Firewall will also be a key device for enhancing security it will control incoming and outgoing data communication through analyzing data packets and giving permissions based on security rules. The Bus Topology is the best accommodate for this network the bus topology is the simplest network topology. Also known as elongated bus, in this topology all computers will be connected to a conterminous cable or a cable joined together to make it contiguous.Ethernet is the leafy vegetable example of a bus topology. distributively computer determines when the network is not absorb and transmits data as needed. Computers devices in a bus apology listen only for transmittal from other computers they do not repeat or forward the transmission on the other computers. It is also expense noting that the channelise in a bus topology travels to both ends of the cable. To keep the signal from bouncing back and forth along the cable, both ends of t he cable in a bus topology will be terminated.